product information
(+/-)-2-(6-Methoxy-2-naphthyl)propionic acid
CAS number: 23981-80-8
Groups: All Chemicals
IUPAC Name: (+/-)-2-(6-Methoxy-2-naphthyl)propionic acid

CAS Number: 23981-80-8

Chemical Formula: C14H14O3

Synonyms: (RS)-Naproxen;2-(6-Methoxy-2-naphthyl)propanoic acid;2-(6-Methoxy-2-naphthyl)propionic acid;2-(6-Methoxynaphthalen-2-yl)propanoic acid;2-(6-Methoxynaphthalen-2-yl)propionic acid;6-Methoxy-2-naphthyl-a-methylacetic acid;DL-2-(6-Methoxy-2-naphthyl)propionic acid;DL-Naproxen;Racemic naproxen;a-(6-Methoxy-2-naphthyl)propionicacid;26159-31-9

Product Info: Naproxen is a drug belong to a class of NSAID (nonsteroidal anti-inflammatory drug acts by inhibiting isoforms of cyclo-oxygenase 1 and 2. It has an activity to treat inflammatory rheumatoid diseases and relieve acute pain. It is effective against period pains, pain after surgery, and fever.

Nonsteroidal Antiinflammatory Drugs (NSAIDs); chemically heterogeneous large groups of drugs which suppress inflammation in a manner similar to steroids, but less side effects of sedation, respiratory depression, or addiction than steroids. They are widely used for the treatment of inflammatory disorders and painful conditions such as rheumatoid arthritis, gout, bursitis, painful menstruation, and headache. They are effective in the relief of pain and fever. NSAIDs inhibit the cyclooxygenase (COX) activity resulting in decreased synthesis of prostaglandin, leukotriene and thromboxane precursors such as the ubiquitous enzyme which catalyzes the initial step in the synthesis of prostanoids. Prostanoid is any of a group of C-20 fatty acids complex with an internal five or six carbon rings such as prostaglandins, prostanoic acid, prostacyclins, and thromboxane; derived from arachidonic acid (C-20 polyunsaturated fatty acid with four cis double bonds). The action or the synthesis of prostanoids are involved in the modulation of a variety of pathophysiologic processes including inflammation, hemostasis, thrombosis, cytoprotection, ulceration, hemodynamics and other the progression of kidney diseases. Thus, NSAIDs as non-selective inhibitors of the cyclooxygenases (both the cyclooxygenase-1 and cyclooxygenase-2 isoenzymes) may have beneficial as well as untoward effects on a variety of human diseases. Low stomach prostanoid levels caused by COX-1 inhibitors can result in ulceration and internal bleeding and perforation. The selective COX-2 inhibitors such as oxicam, meloxicam, and coxibs (celecoxib, rofecoxib, valdecoxib, parecoxib and etoricoxib) do not interfere with COX-1. The most prominent NSAID is aspirin. Nonaspirin NSAIDs can be classified based on chemical structures.
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